An Elusive Diagnosis: Case Reports of Secondary Hemophagocytic Lymphohistiocytosis and Review of Current Literature

Hemophagocytic Lymphohistiocytosis - Case History and Review of Literature

Hemophagocytic lymphohistiocytosis or HLH is a very rare underdiagnosed potentially fatal entity which frequently leads to multiorgan failure and death due to immune dysregulation. It can be either primary which is supposed to be an inherited disorder seen in infancy and childhood or secondary to infections, connective tissue disorders or malignancies which is seen in all ages. The disease mani...

Measles and Secondary Hemophagocytic Lymphohistiocytosis

To the Editor: We found interesting the article by Lupo et al. about a case of fatal measles in an immunocompetent 29-yearold woman (Fatal measles without rash in immunocompetent adult, France; http://dx.doi.org/10.3201/ eid1803.111300). Perhaps, however, the possible diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH) should also have been considered in that setting. HLH is a poten...

Histoplasmosis-Induced Hemophagocytic Lymphohistiocytosis in an Adult Patient: A Case Report and Review of the Literature

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threating immune dysregulation syndrome characterized by persistent activation of the mononuclear phagocytic system leading to uncontrolled systemic hyperinflammatory response. The proliferation and activation of histiocytes and lymphocytes lead to production of large amounts of cytokines, also called cytokine storm. Hematopoiet...

Hemophagocytic lymphohistiocytosis secondary to histoplasmosis

Dengue-associated hemophagocytic lymphohistiocytosis in an adult: A case report and literature review: Erratum

BACKGROUND Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. CASE SUMMARY A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotyp...